What supplement should I take for Fatigue?

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Feeling like a zombie lately? Yawning non-stop with no relief in sight? Feeling tired all the time and still not refreshed when you wake up in the morning? We’ve got some all-natural ingredients to look out for (including our trusty supplement Neurologica® FLOW and SLUMBER) that could have you feeling fresh, energized, and ready to take on the day! Because of its wide mode of operation, there are some interesting ways that scientists are studying how it can be used in human health and wellness:


Ashwagandha is an herb that has been used for centuries in Ayurvedic medicine to promote overall health and wellness. Recent research has found that ashwagandha can also be effective in combatting fatigue1. It works by reducing cortisol levels, which is a hormone associated with stress and fatigue.

Ashwagandha is also an adaptogen, which means it helps the body adapt to stressors and maintain balance2. As a result, it can help improve energy levels and reduce feelings of exhaustion. Additionally, ashwagandha has been found to improve sleep quality, which is crucial for combating fatigue3.

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Rhodiola Rosea

Rhodiola Rosea is another Ayurvedic, adaptogenic herb that is traditionally used to combat stress and fatigue. It has been shown to improve physical and mental performance, reduce fatigue, and enhance mood. Rhodiola Rosea works by increasing the production of dopamine, norepinephrine, and serotonin, neurotransmitters that are involved in mood regulation and energy production.

A meta-analysis of 11 studies4 conducted on over 500 people revealed the potential of Rhodiola in fighting physical and mental fatigue. In eight of these studies, it was found that Rhodiola could improve physical performance and help alleviate mental fatigue. An added benefit was that the consumption of Rhodiola supplements did not result in any significant safety concerns and has a low risk of side effects.

Natural caffeine with L-Theanine

A combination of caffeine and L-theanine has been shown to help improve alertness, focus, and reduce fatigue. Several studies have found that these two compounds work together to enhance mental performance and reduce the negative effects of caffeine, such as jitters or crashes5.

So, next time you need a boost of energy, combine your natural caffeine (coffee or tea) with L-theanine. Neurologica® IGNITE has these two ingredients in the optimal dose, so that you can still enjoy your morning brew.  

Natural caffeine with L Theanine 05
Co Enzyme Q10 06

Co-Enzyme Q10

CoQ10 is a compound naturally produced in the body that comes in different forms such as ubiquinone and ubiquinol. It is found in all cells, but the highest levels are in the heart, kidneys, and liver. CoQ10 is essential for energy production and cell protection from oxidative damage. When CoQ10 go down, it may cause cells to not have the energy they need to function properly, which could lead to fatigue.

A 2022 meta-study6 concluded that CoQ10 is an effective and safe supplement for reducing fatigue symptoms.

Life takes it’s toll, leaving us tired and exhausted.

Fortunately, there are several ways to maintain your energy levels, such as eating a balanced diet, getting enough sleep, and regular exercise. However, these options may not always be possible. That’s when supplements and vitamins come into play, which can help boost your energy when you need it the most. Some supplements are effective for increasing energy during exercise, while others are ideal for providing a quick energy boost.

It is worth noting that all the supplements on this list have a well-established safety profile when used appropriately. Nevertheless, it’s always best to consult with your healthcare provider or a registered dietitian to determine if these supplements are safe for you to use.

Looking for the best all-in-one option?

Neurologica® IGNITE is formulated by pharmacists that have expertly blended the best dosages of Rhodiola, Co-Enzyme Q10, natural caffeine and L-theanine. Convenient, all-day energy to help you get the mental energy you need, without the jitters or crash.

The Neurologica® range was created for mix-and-match. Take IGNITE with FLOW for the best brain supplement combination available globally.

1Biswal, Biswa Mohan, et al. “Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients.” Integrative cancer therapies 12.4 (2013): 312-322.

2Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62

3Abhijit Deshpande, Nushafreen Irani, Ratna Balkrishnan, Irin Rosanna Benny, A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults, Sleep Medicine, Volume 72, 2020, Pages 28-36, ISSN 1389-9457

4Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011 Feb 15;18(4):235-44.

5Haskell CF, Kennedy DO, Milne AL, Wesnes KA, Scholey AB. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol. 2008 Feb;77(2):113-22.

6Tsai IC, Hsu CW, Chang CH, Tseng PT, Chang KV. Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2022 Aug 24;13:883251